{"id":734,"date":"2025-03-12T08:53:15","date_gmt":"2025-03-12T12:53:15","guid":{"rendered":"https:\/\/blogs.bsu.edu\/honors\/?p=734"},"modified":"2025-03-12T08:53:15","modified_gmt":"2025-03-12T12:53:15","slug":"chemistry-research","status":"publish","type":"post","link":"https:\/\/blogs.bsu.edu\/honors\/2025\/03\/12\/chemistry-research\/","title":{"rendered":"Chemistry Research. It Takes A Village: Dr. Konkle&#8217;s Sabbatical Talk"},"content":{"rendered":"<h2>Chemistry Research. It Takes A Village: Dr. Konkle&#8217;s Sabbatical Talk<\/h2>\n<p>(Walker, 2025)<br \/>\n<em>News &amp; Notes<\/em><\/p>\n<p><span data-contrast=\"auto\">On January 23rd, 2025, Associate Professor of Chemistry, Dr. Mary Konkle, gave a presentation on her research on a mitochondrial protein called mitoNEET, which plays a role in aging, neurodegeneration, cancer, and metabolic disease. Her interest in this protein stemmed from the unknown mechanisms of certain drugs treating type 2 diabetes. One potential target of these drugs was mitoNEET.\u00a0<\/span><span data-ccp-props=\"{&quot;335559731&quot;:720}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The first mystery about mitoNEET Dr. Konkle addressed was to determine what it interacts with. By mixing cellular contents with mitoNEET proteins and watching it interact with other molecules, she and her lab were able to determine which proteins mitoNEET binds.\u00a0<\/span><span data-ccp-props=\"{&quot;335559731&quot;:720}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">After determining what proteins mitoNEET can bind, Dr. Konkle and her lab tackled the question of what mitoNEET does to such proteins. They found that it is involved in processes which are essential for preventing oxidative stress in cells. Oxidative stress is a state where the cell has too many unstable molecules to be processed by antioxidants, which can lead to cellular damage and disease.\u00a0<\/span><span data-ccp-props=\"{&quot;335559731&quot;:720}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The next step in her research is to connect what she and her lab discovered about mitoNEET to the broader context of an entire cell.\u00a0<\/span><span data-ccp-props=\"{&quot;335559731&quot;:720}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">A recurring theme in Dr. Konkle\u2019s work is that \u201cinterdisciplinary collaborators are essential.\u201d In addition to involving professional researchers from other fields, Dr. Konkle was a mentor in the Louis Stokes Alliance for Minority Participation (LSAMP), a program which funds the STEM involvement opportunities for anyone who is both a STEM major and a member of a marginalized population. The students in this program have a 96% graduation rate, and most either enter graduate school or become a worker in a STEM field. Overall, Dr. Konkle\u2019s work as both a researcher and a mentor have been vital in expanding the field of science to be more inclusive and more informed. To check out her lab\u2019s most recent publications, follow the links below!<\/span><span data-ccp-props=\"{&quot;335559731&quot;:720}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"auto\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36194135\/#:~:text=Abstract,enzyme%20with%20cysteine%20transaminase%20activity\">MitoNEET as a Transaminase<\/a><\/span><\/b><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36500407\/\"><b><span data-contrast=\"auto\">MitoNEET and Glutamate Dehydrogenase<\/span><\/b><\/a><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chemistry Research. It Takes A Village: Dr. Konkle&#8217;s Sabbatical Talk (Walker, 2025) News &amp; Notes On January 23rd, 2025, Associate Professor of Chemistry, Dr. Mary Konkle, gave a presentation on her research on a mitochondrial protein called mitoNEET, which plays a role in aging, neurodegeneration, cancer, and metabolic disease. Her interest in this protein stemmed [&hellip;]<\/p>\n","protected":false},"author":441,"featured_media":735,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[25,60,96,239,27,77,235,236,237,238],"class_list":["post-734","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-honors-faculty-features","tag-ball-state","tag-ball-state-university","tag-bsu","tag-chemistry","tag-humanities","tag-news-and-notes","tag-presentation","tag-sabbatical-presentation","tag-stem","tag-stem-majors"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Chemistry Research. 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